Intermediate host
From The Art and Popular Culture Encyclopedia
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A secondary host or intermediate host is a host that harbors the parasite only for a short transition period, during which (usually) some developmental stage is completed. For trypanosomes, the cause of sleeping sickness, humans are the primary host, while the tsetse fly is the secondary host. Cestodes (tapeworms) and other parasitic flatworms have complex life-cycles, in which specific developmental stages are completed in a sequence of several different hosts.
As the life cycles of many parasites are not well understood, sometimes the "more important" organism is arbitrarily defined as definitive, and this designation may continue even after it is determined to be incorrect. For example, sludge worms are sometimes considered "intermediate hosts" for whirling disease, even though it is known that the parasite causing the disease reproduces sexually inside them.
In Trichinella spiralis, the roundworm that causes trichinosis, a host has both reproductive adults in its digestive tract and immature juveniles in its muscles, and is therefore considered both an intermediate host and a definitive host.
A paratenic host is similar to an intermediate host, only that it is not needed for the parasite's development cycle to progress. There are also reservoir hosts. A reservoir can harbor a pathogen indefinitely with no ill effects. A single reservoir host may be reinfected several times. The difference between a paratenic and reservoir host is that the latter is a primary host, whereas paratenic hosts serve as "dumps" for non-mature stages of a parasite which they can accumulate in high numbers.
Dicrocoelium dendriticum
Dicrocoelium dendriticum spends its adult life inside the liver of its host. After mating, the eggs are excreted in the feces.
The first intermediate host, the terrestrial snail (Cionella lubrica in the United States), eats the feces, and becomes infected by the larval parasites. The larvae (or cercariae) drill through the wall of the gut and settle in its digestive tract, where they develop into a juvenile stage. The snail tries to defend itself by walling the parasites off in cysts, which it then excretes and leaves behind in the grass.
The second intermediate host, an ant (Formica fusca in the United States), uses the trail of slime as a source of moisture. The ant then swallows a cyst loaded with hundreds of juvenile lancet flukes. The parasites enter the gut and then drift through its body. Most of the cercariae encyst in the haemocoel of the ant and mature into metacercariae, but one moves to the sub-esophageal ganglion (a cluster of nerve cells underneath the esophagus). Infected ants may contain 100 metacercariae, and a high percentage of ants may be infected. Typical infections in cattle may be in the tens of thousands of adult worms. There, the fluke takes control of the ant's actions by manipulating these nerves. As evening approaches and the air cools, the infested ant is drawn away from other members of the colony and upward to the top of a blade of grass. Once there, it clamps its mandibles onto the top of the blade and stays there until dawn. Afterward, it goes back to its normal activity at the ant colony. If the host ant were to be subjected to the heat of the direct sun, it would die along with the parasite. Night after night, the ant goes back to the top of a blade of grass until a grazing animal comes along and eats the blade, ingesting the ant along with it, thus putting lancet flukes back inside their host.
They live out their adult lives inside the animal, reproducing so that the cycle begins again.
