From The Art and Popular Culture Encyclopedia
- January 10 – Great fire in the Rialto of Venice.
- March 12 – A huge exotic embassy sent by King Manuel I of Portugal to Pope Leo X arrives in Rome, including Hanno, a white Asian elephant.
- Nicolaus Copernicus's "Commentariolus", outlining his theory of heliocentrism, is written by this date
- The earliest printed edition of Saxo Grammaticus' 12th century Scandinavian history Gesta Danorum, edited by Christiern Pedersen from an original found near Lund, is published as Danorum Regum heroumque Historiae by Jodocus Badius in Paris.
- February 8 – Daniele Barbaro, Venetian churchman, diplomat and scholar (d. 1570)
- December 31 – Vesalius, Flemish anatomist (d. 1564)
- March 11 – Donato Bramante, Italian architect (b. 1444)
- July 20 – György Dózsa, Transylvanian peasant revolt leader (b. 1470)
- November 28 – Hartmann Schedel, cartographer (b. 1440)