Serotonin antagonist and reuptake inhibitor
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Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also act as α1-adrenergic receptor antagonists. The majority of the currently marketed SARIs belong to the phenylpiperazine class of compounds.
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See also
- Noradrenergic and specific serotonergic antidepressant (NaSSA)
- Norepinephrine-dopamine disinhibitor (NDDI)
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