René Descartes' (1596–1650) illustration of the stimulus–response cycle of visual perception, nervous system (pineal gland) and motor system  

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René Descartes' (1596–1650) illustration of the stimulus–response cycle of visual perception, nervous system (pineal gland) and motor system[1][2][3].

Descartes believed inputs are passed on by the sensory organs to the pineal gland in the brain and from there to the immaterial spirit.

On the pineal gland he wrote:

My view is that this gland is the principal seat of the soul, and the place in which all our thoughts are formed.[4]
--in a letter of January 29, 1640 from Descartes to Lazare Meyssonnier
[The] mechanism of our body is so constructed that simply by this gland's being moved in any way by the soul or by any other cause, it drives the surrounding spirits towards the pores of the brain, which direct them through the nerves to the muscles; and in this way the gland makes the spirits move the limbs.[5]
-- Passions of the soul

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