Pierre Marie  

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Train wreck at Montparnasse (October 22, 1895) by Studio Lévy and Sons.
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Train wreck at Montparnasse (October 22, 1895) by Studio Lévy and Sons.

Pierre Marie (9 September 1853 – 13 April 1940) was a French neurologist who was a native of Paris.

After finishing medical school, he became an intern in 1878, where he was an assistant to the famous neurologist Jean-Martin Charcot (1825–1893) at the Salpêtrière and Bicêtre Hospitals. In 1883 he received his medical doctorate with a graduate thesis on Basedow’s disease, and in 1888 was promoted to médecin des hôpitaux in Paris. In 1907 he attained the chair of pathological anatomy at the Faculty of Medicine, and in 1917 was appointed to the chair of neurology, a position he held until 1925. In 1911 Marie became a member of the Académie de Médecine.

One of Marie's earlier contributions was a description of a disorder of the pituitary gland known as acromegaly. His analysis of the disease was an important contribution in the emerging field of endocrinology. Marie is also credited as the first to describe pulmonary hypertrophic osteoarthropathy, cleidocranial dysostosis and rhizomelic spondylosis. In his extensive research of aphasia, his views concerning language disorders sharply contrasted the generally accepted views of Paul Broca (1824–1880). In 1907, he was the first person to describe the speech production disorder of foreign accent syndrome.

Marie was the first general secretary of the Société Française de Neurologie, and with Edouard Brissaud (1852–1909), he was co-founder of the journal Revue neurologique. His name is associated with the eponymous Charcot-Marie-Tooth disease; which is named along with Jean-Martin Charcot and Howard Henry Tooth (1856–1925). This disease is characterized by gradual progressive loss of muscle tissue in the legs, arms and feet. It is considered one of the more common hereditary neurological diseases.

Associated eponyms

Selected writings

  • Des formes frustes de la maladie de Basedow. Thèse de doctorat, Paris, 1883.
  • Sur deux cas d’acromégalie. 1886.
  • Sur une form particulière d'atrophie musculaire progressive; souvent familiale, débutant par les pieds et les jambes et atteignant tard les mains. With Jean Martin Charcot. 1886
  • "Essays on Acromegaly". with bibliography and appendix of cases by other authors. London, 1891.
  • Leçons sur les maladies de la moëlle épinière. Paris, 1892. English translation by M. Lubbock as "Lectures on Diseases of the Spinal Cord". London, 1895.
  • Sur l'hérédo-ataxie cérébelleuse. Semaine médicale, Paris, 1893, 13: 444.
  • L’évolution du langage considéré au point de vue de l’étude de l’Aphasie. 1897.
  • Dysostose cléido-crânienne héréditaire. with Paul Sainton (1868-1958). 1897.
  • Spondylose rhizomélique. 1898.
  • Neurologie. 2 volumes; 1923.




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