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Ossip Zadkine (July 14, 1890 – November 25, 1967) was an Russian Jewish artist and sculptor.

Born in Vitebsk, Belarus, then Russian Empire, of Jewish and Scottish extraction, Zadkine is primarily known as a sculptor but also produced paintings and lithographs.

After attending art school in London, Zadkine settled in Paris about 1910, where he became part of the new Cubist movement (1914-1925). After this time, he developed an original style, strongly influenced by primitive arts.

He served as a stretcher-bearer in World War I, and was wounded in action. He spent the years of World War II in exile in America. His best-known work is probably the sculpture "The Destroyed City" (1953), a memorial to the destruction of the center of the Dutch city Rotterdam by the Germans in 1940. He taught at his Zadkine School of Sculpture.

Ossip Zadkine died in Paris at the age of 77 and was interred in the Cimetière du Montparnasse.