Major depressive episode  

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A major depressive episode is the cluster of symptoms of major depressive disorder. The description has been formalised in psychiatric diagnostic criteria such as the DSM-IV and ICD-10, and is characterized by severe, highly persistent depression, and a loss of interest or pleasure in everyday activities, which is often manifested by lack of appetite, chronic fatigue, and sleep disturbances (somnipathy). The individual may think about suicide, and indeed an increased risk of actual suicide is present.

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