List of fictional scientists and engineers  

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The following is a list of fictional mad scientists in cultural sources (literature, movies, comics, etc.). They are split into pre- and post-1945, as the images of mad scientists changed and proliferated in the years following the atomic bombings of Hiroshima and Nagasaki, and the increased role of scientists following World War II.

Before 1945

Literature

• Victor Frankenstein, creator of Frankenstein's monster, in the novel Frankenstein, or the Modern Prometheus by Mary Shelley (1818).
• Nathaniel Hawthorne, in his short story "The Birthmark" (1843), shows a scientist named Aylmer who, while perhaps not mad, is certainly overconfident, and whose meddling with nature brings about tragedy.
• The following year, Hawthorne wrote "Rappaccini's Daughter," in which medieval Paduan naturalist Giancomo Rappaccini performs botanical and toxicological experiments on his own daughter.
• Nathaniel Hawthorne also wrote the story "Artist of the Beautiful", in which Owen Warland, a quirky clock-maker, seeks to discover/create perpetual motion, and is thought mad by the townspeople.
• Robert Louis Stevenson's The Strange Case of Dr. Jekyll and Mr. Hyde (1886) portrays the essentially humane experimenter driven to madness and suicide by the nature of his science.
• Several (but not all) of Jules Verne's novels feature a mad scientist. Some of these are humorous, who fail everything they try; others are shown as rather serious and even dangerous characters. A partial list follows.
  • The main characters of The Chase of the Golden Meteor (La Chasse au météore) (1908) are three mad scientists: Dean Forsyth and Sidney Hudelson, rivalling astronomers, and the eccentric inventor Xirdal Zephyrin.
  • Thomas Roch in Facing the Flag (Face au drapeau) (1896) is a typical mad scientist in that he doesn't realize his powers are used for evil purposes.
  • Captain Nemo, the rich protagonist who builds a submarine appears in two novels Twenty Thousand Leagues Under the Sea (1870) and The Mysterious Island (1874). However, he appears more as a vigilante, an explorer and a super engineer, than a god-playing mad scientist. None of his inventions (not even the Nautilus - which is much more a means to travel and discover the undersea world, than a battle machine) could ever be questioned on any moral ground. Despite being a misanthrope (who still has faith in some good men and who still cares for the underdog), he has no plan to dominate or destroy the world. Furthermore, his research and experiments never involved any living being.
  • Arguably, the main character of Mathias Sandorf (1885).
  • Professor Lidenbrock from Journey to the Center of the Earth (1864).
  • J. T. Matson (and other characters) in Barbicane and Co. (Sans dessus dessous) (1889) and also in From the Earth to the Moon (1865) who enjoys making giant cannons.
  • Off on a comet (orig. title Hector Servadac, 1877) has the astronomer Palmyrin Rosette as an important character.
  • In Search of the Castaways (1865) has Jacques Paganel, a geographer who becomes involved in the story by accident: he is so forgetful that he's boarded the wrong ship. Nevertheless, he is a very famous scientist in the book, has three lines of titles and three middle names.
  • John Hatteras from The Adventures of Captain Hatteras (Template:Lang-fr, 1864) can be counted as one as well.
  • Carpathian Castle (1892) has a mad scientist named "Orfanik".
• H. G. Wells' The Island of Dr. Moreau (1896) carried Frankensteinian experimentation a step further with its mad scientist Dr. Moreau, contrasting it with an idyllic 'natural' South Sea island setting. Several film versions were made (such as The Island of Lost Souls (1933)).
• The Harold MacGrath 1920 novel The Drums of Jeopardy had a Russian mad scientist named "Boris Karlov" reported to be the source for the stage name adopted by actor Boris Karloff.
• Dr. Herbert West, a Frankenstein-like doctor obsessed with bringing the dead back to life, in H. P. Lovecraft's novella "Herbert West, Reanimator" (1922).
• Griffin, from The Invisible Man (1897) by H.G. Wells. Griffin discovers the secret of invisibility, but the process sends him into murderous insanity.
• Vladimir Ipat'evich Persikov, a specialist in reptiles, in The Fatal Eggs (1924) by Mikhail Bulgakov.
• Philip Philippovich Preobrazhensky who implants human testicles and pituitary gland into a stray dog named Sharik, in Heart of a Dog (1925) by Mikhail Bulgakov.
• Ras Thavas, who performs grotesque human experiments in Edgar Rice Burroughs' The Master Mind of Mars (1928) and Synthetic Men of Mars (1940).
• Phor Tak, the discoverer of invisibility in Edgar Rice Burroughs' 1930 science-fiction novel, A Fighting Man of Mars.
• Dr Rance Mandarin, a.k.a. Doctor Death, from the novels "12 Must Die", "The Gray Creatures" and "The Shriveling Murders" which appeared in three issues of the pulp magazine Doctor Death in 1935.
• The 1917 short story "Re-Animator" by H.P. Lovecraft features Herbert West, a ambitious young scientist who believes that he can bring the dead back to life.

Movies

• The Cabinet of Dr. Caligari (1919) is a silent film featuring the mad hypnotic doctor and his sleepwalking assistant.
• Dr. Mabuse, most famous from the films made about him by Fritz Lang
• C. A. Rotwang in Fritz Lang's Metropolis (1927).
• Dr. Frankenstein in several movie versions.
• Dr. Jack Griffin, in the film The Invisible Man (1933), adapted from the Wells novel.
• Dr. Janos Rukh, in the film The Invisible Ray (1936). Dr. Rukh discovers a radioactive ray that cures blindness but causes him to develop a murderous paranoid rage against other scientists, whom he accuses of stealing his discovery.
• Dr. Thorkel, in the film Dr. Cyclops (1940). Dr. Thorkel shrinks opponents of his unorthodox experimentation with radium.
• Armand Tesla, Romanian scientist/vampire played by Bela Lugosi in The Return of the Vampire (1944)

After 1945

Novels

• Dr. Adam Burkhardt, in the Frank Peretti novel Monster, who mutates a chimpanzee to the point where it grows into a bigfoot-like creature, after which it escapes the lab and gruesomely kills several people.
• Dr. Jacob Burroughs, Colonel, A.U.S. from Robert A. Heinlein's The Number of the Beast (1980) (Although Heinlein used the term "Mad Scientist" to describe him, he does not exhibit many of the characteristics.)
• The unnamed narrator in Thomas Ligotti's short story "The Chymist".
• Damontir the Mad, in Dave Morris's gamebook Temple of Flame.
• Dr. Hugo Grief from the Alex Rider book Point Blanc.
• Various parodies in Terry Pratchett stories, including Hugo Lavish in Making Money and Igor the manservant.
• Opal Koboi, in the Artemis Fowl series by Eoin Colfer
• Xavier Mace, a recurring adversary in a 1990s series of Tom Swift, Jr. books.
• The Mad Scientists' Club: a book series that portrayed seven "normal" boys, one an inventive genius, who go on many crazy and wacky adventures.
• Dr. Ignacio Metz, who did unorthodox experiments with dolphin uplift in David Brin's Startide Rising.
• Mole, the genius inventor and hunter of Nazis in the Burke series of novels by Andrew Vachss.
• Characters from the James Bond series of novels:
  • Dr. Julius No from Dr. No.
  • Dr. Anton Murik in Licence Renewed.
• Dr. Roger Nordhagen, a plastic surgeon with something nasty in the basement, in Thomas Tessier's novel Finishing Touches.
• Novai (a.k.a. Theodore Nova) and Blitz from the storyline The Lab.
• The Horrible Math Teacher in the GrailQuest gamebooks.
• John Roe O'Neill, in the Frank Herbert novel The White Plague.
• Dr. Fabian Rosten, in High Times.
• De Selby, an eccentric Irish philosopher and scientist in The Third Policeman and The Dalkey Archive by Flann O'Brien.
• Vergil Ulam, in the Greg Bear novel Blood Music.
• Dr. Lazlo Zand, from the Robotech novels by Jack Mckinney.
• Crake from Oryx and Crake by Margaret Atwood.
• Doctor Impossible, from Soon I Will Be Invincible by Austin Grossman.
• The Doctor, from Ecstasia and Primavera by Francesca Lia Block.
• Lois Wilson, from Brainchild by Andrew Neiderman.
• Melvin Dobbs, from Resurrection Dreams by Richard Laymon.
• Jamie Angelo, from Beauty by Brian D'Amato.
• Dr. Victor Beaufort and Dr. Griffin, from The Jigsaw Woman by Kim Antieau.
• Dr. Wade Ormont, from L. Sprague de Camp's short story "Judgment Day".
• Sir Darren Penward, from John Brosnan's Carnosaur.

Movies

• Dr. Strangelove, the title character (1964)
• Dr. Benway in Naked Lunch (1991)
• Ernst Stavro Blofeld from James Bond, head of SPECTRE.
• Professor Ned Brainard The Absent-Minded Professor (1961)
• Dr. Emmett Brown in the Back to the Future trilogy
• Dr. Seth Brundle in David Cronenberg's remake of The Fly
• The Skeksis skekTek in The Dark Crystal [1982]
• Dr. Eldon Tyrell in Blade Runner (1982)
• Sebastian Caine, in Hollow Man (2000)
• Max Cohen, in Pi (1998)
• Sir August DeWynter, in The Avengers (1998)
• Kevin Dornwinkle, in Invisible Maniac (1990)
• Dr. Durand Durand, in Barbarella (1968)
• Dr. Evil, nemesis of Austin Powers
• Dr. Finkelstein in The Nightmare Before Christmas (1993)
• Dr. Otto Frank, in Monstrosity (1964)
• Dr. Victor Frankenstein (in the film versions, at least)
• Dr. Elaine Frederick, in Flesh Feast (1970)
• Dr. Frank N. Furter, in The Rocky Horror Picture Show (1975)
• Cosmo and Nation McKinley, in Shock Treatment (1981)
• Tania Frankenstein, in Lady Frankenstein (1971)
• Dr. Maria Frankenstein, in Jesse James Meets Frankenstein's Daughter (1966)
• Professor Foot in Help! (1965)
• The protagonists of Ghostbusters
• Dr. Charles Girard, in Terror Is a Man (1959)
• Dr. Gulk, in Supersonic Man (1979)
• Dr. Susan Harris, in Invasion of the Bee Girls (1973)
• Dr. Paul Holliston, in Embryo (1976)
• Professor Julius Kelp in The Nutty Professor (1963)
• Professor Sherman Klump from The Nutty Professor (1996 film) and Nutty Professor II: The Klumps
• Dr. Kobras, in Puma Man (1980)
• Baron von Kratzmar in Adele Hasn't Had Her Dinner Yet (1977)
• Krank, and the doctor who made him, in The City of Lost Children (1995)
• Doctor Kraspin, in The Humanoid (1979)
• Dr. Kurt Leopold, Zaat (1972)
• Dr. Emilio Lizardo, in The Adventures of Buckaroo Banzai Across the 8th Dimension (1984)
• Dr. Logan - Day of the Dead (nicknamed "Dr. Frankenstein")
• Dr. Lorca, in the film Mad Doctor of Blood Island (1968)
• Dr. Arliss Loveless, in Wild Wild West (1999)
• Professor Mason, in Death Dimension (1978)
• Dr. Mifune, in Terror of Mechagodzilla
• Dr. Edward Morbius, in Forbidden Planet (1956)
• Edward Nigma, aka The Riddler, in Batman Forever
• Jason Woodrue in "Batman & Robin" (1997)
• Dr. No, and various other characters from the James Bond series of films
• Professor Nolter, in The Mutations (1973)
• J. Frank Parnell, in Repo Man (1984)
• The Abominable Dr. Phibes (Vincent Price) in the series The Abominable Dr. Phibes
• Philo in UHF (While he is not exactly mad, he is absent-minded, and does work and live in a lab/workshop.)
• Dr. Hans Reinhardt, in The Black Hole (1979)
• Michael Sharrington, in Graveyard of Horror (1971)
• Dr. Tolian Soran from the Star Trek film Star Trek Generations
• Dr. Carl Stoner, in Ssssss (1973)
• Syndrome/Buddy Pine, in The Incredibles (2004)
• Dr. Jane Tiptree in Carnosaur (film) (1993)
• Dr. Sy N. Tist, from the Mad Scientist series
• Dr. Totenkopf, in Sky Captain and the World of Tomorrow (2004)
• Dr. Richard Benjamin Vannacutt from House on Haunted Hill (1999)
• Dr. Eric Vornoff (Bela Lugosi) in Bride of the Monster
• Dr. Calvin Weber in Blast from the Past (1997)
• Professor Wendland, in Superargo (1968)
• Dr. Gediman, in Alien Resurrection (1997)
• Dr. Herbert West, in Re-Animator (1985)
• Nathaniel Pickman Wingate in Kamillions (1989)
• Professor MacKrill, in Help! I'm a Fish (2001)
• Doctor Rush, the female scientist from Black Sheep (2007 film)
• Dr. Horrible, in Dr. Horrible's Sing-Along Blog (2008)
• Dr. Cockroach (Hugh Laurie), in "Monsters vs. Aliens", the 2009 DreamWorks animated film

Television series

• Dr. Necros , from the TV series Aaron Stone, A member of the organization 'Omega Defiance'. He is a mad scientist who specializes in creating dangerous serums and toxins. His name is derived from a Greek term meaning "death".
• Dr. Walter Bishop, from Fringe
• Dr. Sheldon Lee Cooper, from The Big Bang Theory has tendencies to be a real mad scientist. His ideas are usually called "mad" or "insane" (e.g. build a death ray or breed a Griffin).
• Dr. Bunsen Honeydew from The Muppet Show
• Jha'Dur (AKA Deathwalker), from the Babylon 5 episode "Deathwalker"
• Professor Maggie Walsh, from the TV series Buffy the Vampire Slayer
• Dr. Crell Moset , from the TV series Star Trek Voyager
• Dr. Clayton Forrester, from Mystery Science Theater 3000, named after the hero scientist in the 1953 film The War of the Worlds
• Dr. Laurence Erhardt, from Mystery Science Theater 3000. Appeared in the initial locally broadcast season, and in the first national season along with Dr. Clayton Forrester.
• Pearl Forrester from Mystery Science Theater 3000. The mother of Clayton, she took up mad science and resumed the experiments to get revenge on the Satellite of Love crew although she was unaccredited.
• Dr. Yes, and various other parodic characters in Get Smart
• Dr. Miguelito Loveless, in the 1960s series The Wild Wild West
• Dr. Momus Alexander Morgus from Morgus Presents!
• Johann Wilhelm Möbius in Dürrenmatt's satiric drama The Physicists (1962)
• Namtar, from Farscape
• Dr. Chaotica from the "Bride of Chaotica" episode in Star Trek: Voyager
• Dr. Paul Museveni from Andromeda
• Doctor Who, Davros, the Rani, Doctor Mehendri Solon, Taren Capel, Professor Zaroff and Lazarus, from Doctor Who
• Degra, from Star Trek: Enterprise
• Dr. Arik Soong, from Star Trek: Enterprise
• Dr. Phlox (Mirror Universe version), from Star Trek: Enterprise
• Dr. Sparrow from Angel
• Professor Chagrijn from Bassie and Adriaan
• Dr. Julia Hoffman from Dark Shadows
• Dr. Ignatius Faust Fear II from The Mysterious Lab of Dr. Fear horror show from Enid Oklahoma
• Dr. TwoBrains from WordGirl
• Dr. Donald Baxter from Curse of The Blood of The Lizard of Doom who attempts to find a cure for the common burn, but ends up turning people into lizard monsters. (2001)
• Elizabeth, from Wicked Science
• Most of the characters from Eureka
• Dr. Insano from "The Spoony Experiment"
• Topher Brink from the television series "Dollhouse"
• Dr. Andover (played by Robert Englund) is a character in the Fearnet original series "Fear Clinic" This doctor isn't particularly 'mad' though.
• Morgan Freeman's character from "The Electric Company"

Cartoon

• The Professor, from the cartoon series Felix the Cat
• The Evil Scientist from Looney Tunes
• Dr. Hess from the manga/anime Saber Marionette J
• Dr. Agasa from the manga/anime Detective Conan
• Doctor Arkeville, from the cartoon series (but not the comic or toyline) Transformers
• Bighead from The Ambiguously Gay Duo
• Dr. Blight, a female mad scientist specialising in genetic engineering and air pollution, from Captain Planet and the Planeteers
• Dr. Animo from Ben 10
• The Brain, from Animaniacs and Pinky and the Brain
• Dr. Otto Scratchansniff from Animaniacs
• Dr. Reginald Bushroot and Elmo Sputterspark from Darkwing Duck
• Hector Con Carne and Major Dr. Ghastly, from Evil Con Carne
• rotcoD daM, from the cartoon series Sinbad the Sailor
• Dexter and Mandark, of Dexter's Laboratory
• Dr. Drakken (a.k.a. Drew Lipsky), DNAmy (a.k.a. Amy Hall), and Professor Dementor, from the TV series Kim Possible
• Dantalion, also a Crimson Lord in Shakugan no Shana
• Dr. Eyepatch from The Super Milk-chan Show
• Professor Hubert Farnsworth and his nemesis Professor Wernstrom from the cartoon series Futurama
• Professor Fingers, in DoDo, The Kid from Outer Space (1965)
• Carl Foutley (aspiring), on As Told By Ginger
• Professor Frink from The Simpsons
• Dr. Putrid T. Gangreen from the cartoon series Attack of the Killer Tomatoes (1994)
• Dr. Gero, Dr. Myū and Dr. Wheelo from Dragonball Z
• Newton Gimmick in The Adventures of Teddy Ruxpin
• Rear Admiral Ginias Sahalin of Mobile Suit Gundam: The 08th MS Team
• Hugo A Go Go, from the cartoon series Batfink
• Professor Goatsbeard (Dutch original Joachim Sickbock), an anthropomorphic goat, from the Tom Puss/Oliver B. Bumble cartoon series. A statue of the mad scientist can be seen in Rotterdam. [1]
• Professor Grotalent from the French comics/cartoon Spiff and Hercules.
• Washu Hakubi in the anime series Tenchi Muyo!
• Dr. Hell from Go Nagai's manga and anime Mazinger Z
• Doktor Frogg from The League of Super Evil
• Fritz Huhnmorder, from the action figure stop-motion television show, Robot Chicken
• Head Commander Gendo Ikari in Neon Genesis Evangelion
• Dr. Katsuhito Stingray from Bubblegum Crisis Tokyo 2040
• Dr. J, Professor G, Doktor S, Instructor H, and Master O from the anime Gundam Wing
• Dr. Jumba Jookiba, from the Lilo & Stitch cartoons and movies
• Dr. Kamikazi, Bjorn Bjornson and Brainy Yak, from Robotboy
• Dr. Muraki Kazutaka, whose interest in (and applications of) genetics, cloning, and anatomy in general stem from decidedly less than harmless intentions. He's from the anime Yami no Matsuei
• Mayuri Kurotsuchi and Szayel Aporro Granz from Bleach. Kisuke Urahara is worth mention, as while he may not be mad per se, he is a somewhat perverse scientist who creates bizarre inventions.
• Kururu from Keroro Gunsou
• Eiri Masami from Serial Experiments Lain
• Vlad Masters/Vlad Plasmius from Danny Phantom
• Professor Membrane from Invader Zim
• Dr. Viper from SWAT Kats: The Radical Squadron
• Dr. Mephisto from South Park
• Ichiro "Icchan" Mihara from Angelic Layer
• Mojo Jojo and Dick Hardly from The Powerpuff Girls
• Dr. Desty Nova from the anime–manga series Battle Angel Alita, who used Nanotechnology to try to overcome the human Karma
• Professor Finbarr Calamitous, and Doctor Sydney Orville Moist and Jimmy Neutron from The Adventures of Jimmy Neutron: Boy Genius
• Orochimaru, from the manga/anime Naruto. Note that while he is not actually a scientist, he does experiment with justsu in a similar fashion.
• Mr. Paulson, from Teamo Supremo. However, the real mad scientist of the series was an occasional villain named Dr. Droid, who constructed robot look-alikes of everyone because he believed robots to be superior.
• Professor von Proton from The Big Knights, described as "that discraced scientist from village Borodzo". Inventor of the Protonosphere (a time travel machine), and Proton-Power a highly unstable method of power generation fueled by "freely available porcine agricultural by-product".
• Simon Bar Sinister, from the Underdog cartoon (1964)
• Dr. Slump from Dr. Slump
• Dr. Mashirito from Dr. Slump
• Professor Squarkencluck, from the cartoon Dangermouse
• Baxter Stockman and occasionally Donatello and Leatherhead from the Teenage Mutant Ninja Turtles
• Kaolla Su from the manga/anime Love Hina
• Tarantulas, from the Beast Wars animated series
• Professor Tomoe from the manga/anime series Sailor Moon
• Shou Tucker, Zolf Kimblee, and others in Fullmetal Alchemist
• Dr. Nora Wakeman, from the TV series My Life as a Teenage Robot
• Dr. Weird from Aqua Teen Hunger Force
• Phineas J. Whoopee from Tennessee Tuxedo
• Wheeljack, an autobot from the Transformers
• Dr. Zin, from the Jonny Quest cartoon series
• Urpgor, from the cartoon series The Dreamstone
• Voltaire, Doctor B & Doctor K, and Dr. Zagart from the manga/anime Beyblade
• Tracy McBean, from the cartoon of the same name
• Dr. Benjamin Boris Zachary Karbunkle from Biker Mice from Mars
• Muffy Pepperidge from Totally Spies (episode 111)
• Brain Freezer from Johnny Test cartoon Series
• Doctor Thaddeus Venture and Jonas Venture Jr. (as well as the absent Jonas Venture Sr., seen in flashbacks, etc.) from The Venture Bros.
• Doctor Colossus from The Simpsons
• "The Doctor" from the manga and OVA Hellsing. His name is unknown and he is simply referred to as "DOC".
• Dr. Anton Sevarius from Gargoyles
• Dr. Harleen Quinzel (aka Harley Quinn), a mad psychiatrist turned villain from Batman: The Animated Series
• Doctor Hogback from the manga/anime series One Piece
• Sheldon J. Plankton from the cartoon series SpongeBob SquarePants
• Dr Franken Stein, an insane weapons meister & teacher who is deliberate cross of Mary Shelly's Frankenstein/Monster, from the manga/anime series Soul Eater
• The Angry Scientist from Sheep in the Big City
• Dr. Chipotle Jr. and Sr., from El Tigre (TV series)
• Dr. Heinz Doofenshmirtz from Phineas and Ferb
• Azmuth from Ben 10, who would rather have his creation, the Omnitrix, self destruct and rip apart the universe than have it exploited by an enemy.
• Dr. Max Enstein from Frank Enstein
• Kooky von Koopa from The adventures of Super Mario bros. 3
• J.J. Vatos from Ben Edlund's The Tick

Comics

• Professor Shelley and the Necro-Nazis, from John Michael McCarthy's Cadavera
• Doctor Doom, from Marvel Comics, arch-enemy of the Fantastic Four
• Mister Sinister, from Marvel comics
• The Red Ghost, enemy of the Fantastic Four, from Marvel Comics.
• Lex Luthor, from DC Comics, arch-enemy of Superman
• Doctor Sivana from DC Comics
• Norman Osborn (The Green Goblin), Otto Octavius (Doctor Octopus), and Curt Connors (The Lizard) in Spider-Man, went mad and became evil after an experiment mutated or altered them
• Doctor Jonas Harrow, an enemy of Spider-Man
• Egghead and Dr. Henry Pym from Marvel comics
• The Mandarin from Iron Man
• Riff, Dr. Catherine Crabtree, and Dr. Irving Schlock, from Sluggy Freelance.
• Dr. August Hopper a.k.a. The Locust, and Forge (comics) from the X-Men comics
• Dr. Cedric Rawlings from the Captain America comics
• Dr. Light, enemy of the Teen Titans
• Baron Karza from the Micronauts comic book (Marvel)
• Gyro Gearloose from the Scrooge McDuck universe
• Dr. Weekday and Dr. Saruta from the Tezuka manga Phoenix series
• Mad Scientist in Monster in My Pocket #39. In the comicbook, he is clearly Dr. Jekyll and Mr. Hyde, though in the first issue, drawn by Ernie Colon he seems to be a transitional version of the two, and looking more like he came from the eighteenth century than the nineteenth. Both of these were corrected by Gil Kane the following issue. In it and subsequent issues, written by Dwayne McDuffie, he would frequently be force-fed his potion as a significant plot complication.
• Professor Cuthbert Calculus (Professeur Tryphon Tournesol) from The Adventures of Tintin
• Professor Bacterio, from Mortadelo y Filemón
• Prof. Septimus in Blake and Mortimer's "The Yellow Mark"
• Professor Miloch Georgevitch in Blake and Mortimer's "The Diabolical Trap"
• The Count of Champignac and Zorglub from Spirou et Fantasio
• Baron Klaus Wulfenbach, Agatha Heterodyne, and other Sparks, from Phil and Kaja Foglio's Girl Genius comics
• Dr. Helen Narbon, Helen Beta Narbon, Lupin "Wolf" Madblood, and others in the webcomic Narbonic
• Dr. Vanessa Leather, Monster-Maker, in Elizabeth Watasin's Charm School
• Casey and Andy from the webcomic Casey and Andy
• Tedd Verres and Dr. Germahn, from the webcomic El Goonish Shive
• Dr. Otto Bonn, from the webcomic The Polymer City Chronicles
• Dr. Virgil Haas, and other victims of Science Related Memetic Disorder, from the webcomic A Miracle of Science. The lead character, Agent Benjamin Prester of the Vorstellen Police, is a recovered mad scientist who works investigating and preventing mad-science related crimes.
• Nick Wellington and Professor Otto Wisebottom, from the webcomic General Protection Fault
• Gav Van Darin, Danny Hua, King Luca, and Suzy Gee, from the webcomic Nukees
• Dr. Von Richter, the chief villain of the Argentine comic book, Cybersix, and its various adaptations
• Bernie, from the comic strip Doonesbury
• T.O. Morrow, enemy of the Justice League.
• Frederick Willheim creator of cyborg gorilla Cy-Gor, a Spawn villain.
• Kevyn Andreyasn, from the webcomic Schlock Mercenary
• Franklin (Franjinha), from Monica's Gang, a popular Brazilian series.
• Nearly the entire cast of Mad About U.
• Hugo Strange
• Dr. Jonathan Crane (Scarecrow)
• Pamela Isley (Poison Ivy)
• Victor Fries (Mr. Freeze)
• Kirk Langstrom (Man-Bat)
• Doctor Emile Dorian
• Doctor Milo
• Professor Barabas, from the comic books series Spike and Suzy
• Wheeljack, from Transformers
• Barry Ween from The Adventures of Barry Ween Boy Genius
• Erwin "Pee Wee" Talon, from Fred Perry's Gold Digger
• Doktor Sleepless
• Zodon from PS238 by Aaron Williams
• Doctor Finitevus, from Archie Comics' Sonic the Hedgehog (comics) , an archenemy of Knuckles the Echidna

Video games

• Rodyle from Tales of Symphonia
• Izuka from Fire Emblem: Path of Radiance
• Gas-O from Bust A Groove
• Doctor Albert W. Wily, from the video game series Mega Man
• Gate, a Reploid Scientist from Mega Man X6.
• Doctor Weil, a Neo Arcadian in Mega Man Zero series
• Doctor Hans Ubermann, from the Indiana Jones and the Fate of Atlantis adventure game (1992)
• Doctor Neo Cortex, alongside his colleagues Doctor N. Gin, Doctor Nitrus Brio and Doctor Nefarious Tropy from the Crash Bandicoot game series.
• Professor Curien and Goldman, from The House Of The Dead series
• Doctor Synthesis, from Gahan Wilson's The Ultimate Haunted House
• Dr. Caulder, from Advance Wars: Days of Ruin
• Doctor Fred Edison, from adventure games Maniac Mansion and Day of the Tentacle
• Professor Gerald Robotnik, Doctor Eggman's grandfather
• Doctor Ivo "Eggman" Robotnik, from the Sonic the Hedgehog video game series
• Dr. Nefarious from Ratchet & Clank: Up Your Arsenal
• Doctor Brain, from the educative video games Island of Doctor Brain, Castle of Doctor Brain, The Lost Mind of Doctor Brain and The Time Warp of Doctor Brain
• Doctor Proton, from Duke Nukem 1
• Doctor Gregor Hoffman from Crusader: No Remorse
• Doctor Malcolm Betruger, from Doom 3
• Doctor William Birkin, from Resident Evil 2
• Doctor Killjoy, owner and main physician of 'Carnate Institution for the Alienated', whose treatment methods were drastic and lethal, including lobotomy, dismembernment and electro-shock therapy. Appears in The Suffering
• Doctor Muto, titular character of Dr. Muto
• Professor Burnital, Dr. Muto's arch-nemesis
• Doctor Baldhead/Faust, from the Guilty Gear series, an insane medical doctor
• Doctor Bomb, from platform game Bravoman
• Doctor Wallace Breen, Black Mesa Administrator turned puppet dictator of Earth, Half-Life 2.
• Doctor Sludge Vohaul from the Space Quest series.
• Doctor Schabbs and Otto Giftmacher from Wolfenstein 3D.
• Doctor Edward W. Johansson from XIII
• Andross, from game series Star Fox
• Doctor Erasmus Sartorius, from Zork Nemesis
• Professor E. Gadd, from the Mario Games.
• Doctor Ironstein, from the Flight of the Amazon Queen adventure game (1995)
• Doctor Ignatio Mobius, from the Command & Conquer series.
• Guildenstern, a Genma Scientist from the Onimusha series
• Doctor Lugae from Final Fantasy IV
• Cid del Norte Marguez from Final Fantasy VI.
• Professor Hojo from Final Fantasy VII.
• Doctor Odine from Final Fantasy VIII.
• Dr. Cidolfus Demen Bunansa from Final Fantasy XII.
• Vexen from Kingdom Hearts: Chain of Memories.
• Doctor Knarf, from the Sony PlayStation 3D platform game, Jersey Devil.
• Doctor Boskonovitch, from Tekken
• Doctor Jacob Crow, creator of the Timesplitters from Timesplitters: Future Perfect
• Bishop Mandible from Loom
• Henry Stauf from The 7th Guest
• Doctor Willard from Tomb Raider 3
• Doctor Cranium from Quest for Glory IV: Shadows of Darkness
• Doctor Pretorius / Dr. Mobius (the same person) from Quest for Glory V: Dragon Fire
• Garlen from the Klonoa series
• Doctor (George Wilhelm) Krieger from the Far Cry series
• Doctor Crygor and his granddaughter Penny from the WarioWare series of games
• Baron K. Roolenstein from Donkey Kong Country 3: Dixie Kong's Double Trouble!
• Doctor Exavolt from Metal Arms: Glitch in the System
• Doctor Riptide from In Search of Dr. Riptide
• Cranky Kong from Donkey Kong 64
• Professor Elvin Atombender from Impossible Mission
• Doctor Caligosto Loboto from Psychonauts
• Doctor Vu from Sim City 4
• Doctor Kiln from Clayfighter 63 1/3
• Dr. Bad-Boon from Super Monkey Ball 2
• Doctor Beruga from Terranigma
• In Bioshock, Dr Tennenbaum, Dr Suchong, and Dr Steinman.
• Doctor Drago Petrovich Madnar in Metal Gear 2: Solid Snake
• Doctor Thrax in Command & Conquer: Generals Zero Hour
• The Medic from Team Fortress 2; although there is no proof of this, his heavy Germanic accent is a frequent characteristic of the stereotypical mad scientist.
• Professor Monkey-For-A-Head in Earthworm Jim is a mad scientist who throws breakers at the protragonist during 'Level 5'
• Fawful, the villain in the Mario games Mario and Luigi: Superstar Saga and Mario and Luigi: Bowser's Inside Story.
• Dr. Madd from Army Men video games
• Dr Ned ( Dr Zed ) : Borderlands;Dr Ned's Zombie Island
• Amadeus and Oguma from Metal Slug video games
• Dr. Dudley Dabble from Blaster Learning System

Music

• Doctor Steel
• The Mad Sinetist
• Dr. Octagon
• Bartholomäus Scarabäus Peingebreck, a character of the concept album by Samsas Traum Tineoidea oder: Die Folgen einer Nacht - Eine Gothicoper in Blut-Moll

Toys

• Dr. X, from Action Man
• Dr. Ein-O, from Smart Boxes. He is directly based on Albert Einstein.
• Dr. Mindbender, from the cartoon, comic, and toyline G.I. Joe
• Dr. Sy N Tist, from Mad Scientist by Mattel
• Mutran, from BIONICLE
• Dr. Inferno and Dr. D. Zaster, from LEGO Agents
• Dr. Cyber and Professor Millennium, from Lego Time Travels

Audio drama

• Dr.Adventure, host of Adventure Radio
• Dr. Marlin Mazoola, from the adventures of Jack Flanders
• Professor Nebulous, the head of KENT in Nebulous
• Dr. Floyd J. Floyd Jr., from The Radio Adventures of Dr. Floyd

Opera

• Soprano 1 in Facing Goya
• Tenor in Facing Goya