Median lethal dose
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In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a measure of the lethal dose of a toxin, radiation, or pathogen. The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of increased toxicity.
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See also
- Animal testing
- Reed-Muench method
- The dose makes the poison (Latin: sola dosis facit venenum), the toxicology adage that high quantities of any substance is lethal, such as water.
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Other measures of toxicity
- IDLH
- Certain safety factor
- Therapeutic index
- Protective index
- Fixed Dose Procedure to estimate LD50
- Median toxic dose (TD50)
- Lowest published toxic concentration (TCLo)
- Lowest published lethal dose (LDLo)
- EC50 (half maximal effective concentration)
- IC50 (half maximal inhibitory concentration)
- Draize test
- Indicative limit value
- No-observed-adverse-effect level (NOAEL)
- Lowest-observed-adverse-effect level (LOAEL)
- Up-and-down procedure
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Related measures
- TCID50 Tissue Culture Infective Dosage
- EID50 Egg Infective Dosage
- ELD50 Egg Lethal Dosage
- Plaque forming units (pfu)
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